Hot PLR Articles Directory Georgia: moexipril and hydrochlorothiazide

hye-droe-klor-oh-THYE-a-zide, moe-EX-i-pril hye-droe-KLOR-ide

Oral route(Tablet)

ACE inhibitors can cause injury or death to the developing fetus when used during the second and third trimesters. Stop therapy as soon as possible when pregnancy is detected .

Commonly used brand name(s)

In the U.S.

Uniretic

Available Dosage Forms:

Tablet

Therapeutic Class: ACE Inhibitor/Thiazide Combination

Pharmacologic Class: Diuretic

Chemical Class: Thiazide

Uses For moexipril and hydrochlorothiazide

Moexipril and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Hypertension may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Moexipril works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. Hydrochlorothiazide works by helping to reduce the amount of salt and water in the body by acting on the kidneys to increase the flow of urine. Both of these medicines lower blood pressure and increase the supply of blood and oxygen to the heart .

moexipril and hydrochlorothiazide is available only with your doctor's prescription .

Before Using moexipril and hydrochlorothiazide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For moexipril and hydrochlorothiazide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to moexipril and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of moexipril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established .

Geriatric

Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of moexipril and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment of dose in patients receiving moexipril and hydrochlorothiazide combination .

Pregnancy

	Pregnancy Category	Explanation
1st Trimester	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
2nd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.
3rd Trimester	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking moexipril and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using moexipril and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Dofetilide

Using moexipril and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetyldigoxin

Alteplase, Recombinant

Amiloride

Arsenic Trioxide

Azathioprine

Azilsartan Medoxomil

Candesartan Cilexetil

Canrenoate

Deslanoside

Digitalis

Digitoxin

Digoxin

Droperidol

Eplerenone

Eprosartan

Flecainide

Ketanserin

Levomethadyl

Lithium

Losartan

Metildigoxin

Olmesartan Medoxomil

Ouabain

Potassium

Proscillaridin

Sotalol

Spironolactone

Telmisartan

Triamterene

Valsartan

Using moexipril and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Alacepril

Alclofenac

Aliskiren

Apazone

Aspirin

Azosemide

Bemetizide

Benazepril

Bendroflumethiazide

Benoxaprofen

Benzthiazide

Bepridil

Bromfenac

Bufexamac

Bumetanide

Bupivacaine

Buthiazide

Capsaicin

Captopril

Carbamazepine

Carprofen

Celecoxib

Chlorothiazide

Chlorpropamide

Chlorthalidone

Cholestyramine

Cilazapril

Clometacin

Clonixin

Clopamide

Cyclopenthiazide

Cyclophosphamide

Cyclothiazide

Delapril

Dexketoprofen

Diclofenac

Diflunisal

Dipyrone

Droxicam

Enalaprilat

Enalapril Maleate

Ethacrynic Acid

Etodolac

Etofenamate

Felbinac

Fenbufen

Fenoprofen

Fentiazac

Floctafenine

Flufenamic Acid

Flurbiprofen

Fosinopril

Furosemide

Ginkgo

Glipizide

Gold Sodium Thiomalate

Gossypol

Hydrochlorothiazide

Hydroflumethiazide

Ibuprofen

Ibuprofen Lysine

Imidapril

Indapamide

Indomethacin

Indoprofen

Isoxicam

Ketoprofen

Ketorolac

Licorice

Lisinopril

Lornoxicam

Magnesium Salicylate

Meclofenamate

Mefenamic Acid

Meloxicam

Methyclothiazide

Metolazone

Moexipril

Nabumetone

Naproxen

Nepafenac

Niflumic Acid

Nimesulide

Oxaprozin

Oxyphenbutazone

Pentopril

Perindopril

Phenylbutazone

Pirazolac

Piretanide

Piroxicam

Pirprofen

Polythiazide

Propyphenazone

Proquazone

Quinapril

Quinethazone

Ramipril

Salicylic Acid

Salsalate

Spirapril

Sulindac

Suprofen

Temocapril

Tenidap

Tenoxicam

Tiaprofenic Acid

Tolmetin

Topiramate

Torsemide

Trandolapril

Trichlormethiazide

Xipamide

Zofenopril

Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of moexipril and hydrochlorothiazide

In addition to the use of moexipril and hydrochlorothiazide, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that moexipril and hydrochlorothiazide will not cure your high blood pressure but it does help control it. Therefore, you must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

It is best to take moexipril and hydrochlorothiazide on an empty stomach at least 1 hour before eating any food .

Dosing

The dose of moexipril and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of moexipril and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For high blood pressure:
  - Adults—1 or 2 tablets once a day.
  - Children—Use and dose must be determined by your doctor .

Missed Dose

If you miss a dose of moexipril and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using moexipril and hydrochlorothiazide

It is very important that your doctor check your progress at regular visits to make sure moexipril and hydrochlorothiazide is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects .

Using moexipril and hydrochlorothiazide while you are pregnant can harm your unborn baby. If you think you have become pregnant while using moexipril and hydrochlorothiazide, tell your doctor right away .

Stop using moexipril and hydrochlorothiazide and call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema .

Stop using moexipril and hydrochlorothiazide and call your doctor right away if you have severe stomach pain. This could be a symptom of a condition called intestinal angioedema .

You may experience lightheadedness during the first few days with moexipril and hydrochlorothiazide. If this becomes severe and you faint, stop using moexipril and hydrochlorothiazide and talk to your doctor right away .

Tell your doctor immediately if you have any signs of infection such as chills, sore throat, or fever. These may be symptoms of an immune system condition called neutropenia .

If your symptoms do not improve within a few days or if they become worse, check with your doctor .

moexipril and hydrochlorothiazide may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor .

Check with your doctor right away if you have symptoms of jaundice (yellow skin or eyes) because these may be signs of a serious liver condition .

moexipril and hydrochlorothiazide may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor .

Make sure any doctor or dentist who treats you knows that you are using moexipril and hydrochlorothiazide. You may need to stop using moexipril and hydrochlorothiazide several days before having surgery or medical tests .

moexipril and hydrochlorothiazide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision

confusion

decreased urination

dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly

dry mouth

fast, slow, or irregular heartbeat

muscle cramps or pain

numbness, tingling, pain, or weakness in hands or feet

rapid breathing

seizures

sunken eyes

sweating

thirst

trembling

unusual tiredness or weakness

weakness and heaviness of legs

wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Cough

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: moexipril and hydrochlorothiazide side effects (in more detail)

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Hot PLR Articles Directory Georgia

Thursday, October 27, 2016

moexipril and hydrochlorothiazide